Fragment-Based Drug Discovery
by Steven Howard, Harren Jhoti, Chris Abell, Martin Drysdale, David Thurston, Daniel A Erlanson, Tony Giannetti, Isabelle Krimm, Michael Hann, Peter Kutchukian, Terry Hughes, Christina Spry, Iwan de Esch, Miles Congreve, Roderick Hubbard, Paul Bamborough
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Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique.
This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.
- Royal Society of Chemistry, June 2015
Royal Society of Chemistry
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