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Synopsis

A practice-oriented desktop reference for medical professionals,toxicologists and pharmaceutical researchers, this handbookprovides
systematic coverage of the metabolic pathways of all major classesof xenobiotics in the human body. The first part comprehensivelyreviews
the main enzyme systems involved in biotransformation and how theyare orchestrated in the body, while parts two to four cover thethree
main classes of xenobiotics: drugs, natural products, environmentalpollutants. The part on drugs includes more than 300 substancesfrom
five major therapeutic groups (central nervous system,cardiovascular system, cancer, infection, and pain) as well as mostdrugs of abuse

including nicotine, alcohol and "designer" drugs. Selected,well-documented case studies from the most important xenobioticsclasses illustrate general principles of metabolism, making thisequally useful for teaching courses on pharmacology, drugmetabolism or molecular
toxicology.
Of particular interest, and unique to this volume is the inclusionof a wide range of additional xenobiotic compounds, including foodsupplements, herbal preparations, and agrochemicals.

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