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Synopsis

The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skins outermost layer, acts as the human bodys primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction.

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