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Synopsis

Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications critically evaluates thebasic concepts and methodologies of conventional biomarkers as wellas current state-of-the-art assays for measuring antioxidantactivity/oxidative stress and their practical applications. .Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications will be of a greatinterest to scientists who are involved in basic research onoxidation, applied scientists evaluating the effects ofnutraceuticals or pharmaceutical compounds on antioxidantactivity/oxidative stress, and physicians who want to understandthe degree of oxidative damage in patients with certain chronicdiseases.

Discovering sensitive and specific biomarkers for systemicoxidative damage is essential to understand the role of oxidativestress in human disease. Once these roles are clearly understood,we are able to identify novel drug and nutraceutical targets. Thisvolume goes beyond conventional analytical methods of measuringoverall antioxidant activity and provides insight to the discoveryof biomarkers that reveal information on specific areas ofoxidative stress. Contributed by an international list of experts,Biomarkers for Antioxidant Defense and Oxidative Damage:Principles and Practical Applications describes bothconventional biomarkers and recent developments in this area.

Special Features:

  • Discusses conventional biomarkers as well as recent advancesfor measuring antioxidants and oxidative stress
  • Biomarkers for lipid peroxidation: isoprostane,hydroxyloctadecaenoic acid, oxysterols, and reactive carbonylspecies from lipid peroxidation
  • Biomarkers for protein oxidation: carbonylation, tyrosineoxidation, ubiquitin-conjugation
  • Biomarkers for DNA oxidative damage: comet assay, hydroxylatednucleotides, and exocylcic DNA adducts
  • Recently developed biomarkers from cutting-edge technology

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