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Synopsis

With its clear, straightforward presentation, this text enables youto grasp all the fundamental concepts of pharmacokinetics andpharmacodynamics. This will allow you to understand the time courseof drug response and dosing regimen design. Clinical models forconcentration and response are described and built from the basicconcepts presented in earlier chapters. Your understanding of thematerial will be enhanced by guided computer exercises conducted ona companion website. Simulations will allow you to visualize drugbehavior, experiment with different dosing regimens, and observethe influence of patient characteristics and model parameters. Thismakes the book ideal for self-study.

By including clinical models of agonism, indirect drug effects,tolerance, signal transduction, and disease progression, authorSara Rosenbaum has created a work that stands out amongintroductory-level textbooks in this area.You'll find severalfeatures throughout the text to help you better understand andapply key concepts:

  • Three fictitious drugs are used throughout the text toprogressively illustrate the development and application ofpharmacokinetic and pharmacodynamic principles

  • Exercises at the end of each chapter reinforce the concepts andprovide the opportunity to perform and solve common dosingproblems

  • Detailed instructions let you create custom Excel worksheets toperform simple pharmacokinetic analyses

Because this is an introductory textbook, the material ispresented as simply as possible. As a result, you'll find it easyto gain an accurate, working knowledge of all the core principles,apply them to optimize dosing regimens, and evaluate the clinicalpharmacokinetic and pharmacodynamic literature.

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